pituitary apoplexy |
Disease ID | 759 |
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Disease | pituitary apoplexy |
Definition | The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA. |
Synonym | apoplexy, pituitary pituitary apoplexy (disorder) pituitary apoplexy [disease/finding] pituitary gland apoplexy |
Orphanet | |
DOID | |
UMLS | C0032001 |
MeSH | |
SNOMED-CT | |
Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:38) C0001430 | adenoma | 3 C0011848 | diabetes insipidus | 3 C0011847 | diabetes | 3 C0032000 | pituitary adenoma | 3 C0854486 | functioning pituitary adenoma | 2 C0028866 | third nerve palsy | 2 C0007785 | cerebral infarct | 2 C0338078 | non-functioning pituitary adenoma | 2 C0007785 | cerebral infarction | 2 C0019100 | dengue hemorrhagic fever | 2 C0032002 | pituitary disease | 1 C0151311 | cranial nerve palsy | 1 C0007121 | bronchogenic carcinoma | 1 C0456909 | blindness | 1 C0022116 | ischemia | 1 C0019937 | horner's syndrome | 1 C0029089 | ophthalmoplegia | 1 C0001623 | adrenal insufficiency | 1 C0007113 | rectal cancer | 1 C0020635 | hypopituitarism | 1 C0028866 | oculomotor nerve palsy | 1 C0009402 | colorectal cancer | 1 C0206734 | hemangioblastoma | 1 C0242342 | sheehan's syndrome | 1 C0221406 | cushing's disease | 1 C0007785 | cerebral ischemia | 1 C0442874 | neuropathy | 1 C0376358 | prostate cancer | 1 C0155320 | cortical blindness | 1 C0271355 | abducens nerve palsy | 1 C0740392 | middle cerebral artery infarction | 1 C1565489 | renal insufficiency | 1 C0011880 | diabetic ketoacidosis | 1 C0040034 | thrombocytopenia | 1 C0020635 | pituitary deficiency | 1 C0242343 | panhypopituitarism | 1 C0001206 | acromegaly | 1 C0029134 | optic neuritis | 1 |
Curated Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
Inferring Gene | (Waiting for update.) |
Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:10) 551 | AVP | 1.972 | DISEASES 60495 | HPSE2 | 2.116 | DISEASES 3712 | IVD | 1.587 | DISEASES 3713 | IVL | 1.383 | DISEASES 102723508 | KANTR | 1.726 | DISEASES 4221 | MEN1 | 1.637 | DISEASES 4782 | NFIC | 2.058 | DISEASES 4878 | NPPA | 1.267 | DISEASES 29072 | SETD2 | 1.776 | DISEASES 26136 | TES | 1.989 | DISEASES |
Locus | (Waiting for update.) |
Disease ID | 759 |
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Disease | pituitary apoplexy |
Manually Symptom | UMLS | Name(Total Manually Symptoms:16) C1839611 | n syndrome C0917798 | cerebral ischaemia C0752244 | rathke's cleft cyst C0751815 | internal carotid artery dissection C0687720 | central diabetes insipidus C0456909 | blindness C0240059 | intraventricular hemorrhage C0221406 | cushing's disease C0085616 | vasospasm C0038454 | stroke C0029134 | optic neuritis C0028866 | oculomotor nerve palsy C0022972 | eaton-lambert syndrome C0017547 | gigantism C0007785 | cerebral infarct C0002418 | amblyopia |
Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:6) C0038454 | stroke | 2 C0007785 | cerebral infarct | 2 C0456909 | blindness | 1 C0028866 | oculomotor nerve palsy | 1 C0221406 | cushing's disease | 1 C0029134 | optic neuritis | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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(Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
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(Waiting for update.) |
All Snps(Total Genotypes:0) | |
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(Waiting for update.) |
GWASdb Annotation(Total Genotypes:0) | |
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(Waiting for update.) |
GWASdb Snp Trait(Total Genotypes:0) | |
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(Waiting for update.) |
Mapped by lexical matching(Total Items:8) | ||||
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HP ID | HP Name | MP ID | MP Name | Annotation |
HP:0000845 | Growth hormone excess | MP:0003497 | insensitivity to parathyroid hormone | no changes in calcium homeostasis in response to endogenous or exogenous hormone |
HP:0001895 | Normochromic anemia | MP:0001585 | hemolytic anemia | deficiency of red cells resulting from an increased rate of erythrocyte destruction |
HP:0002893 | Pituitary adenoma | MP:0013383 | increased sebaceous gland adenoma incidence | greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any sebaceous gland, occurring in a specific population in a given time period |
HP:0000824 | Growth hormone deficiency | MP:0003965 | abnormal pituitary hormone level | aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary |
HP:0006824 | Cranial nerve paralysis | MP:0006303 | abnormal retinal nerve fiber layer morphology | any structural anomaly of the layer of the retina formed by expansion of the fibers of the optic nerve |
HP:0000622 | Blurred vision | MP:0002090 | abnormal vision | inability or decreased ability to see |
HP:0002017 | Nausea and vomiting | MP:0010426 | abnormal heart and great artery attachment | any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta |
HP:0007663 | Reduced visual acuity | MP:0006149 | decreased visual acuity | loss of visual acuity or ability to distinguish small details |
Mapped by homologous gene(Total Items:34) | ||||
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HP ID | HP Name | MP ID | MP Name | Annotation |
HP:0001578 | Hypercortisolism | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
HP:0000845 | Growth hormone excess | MP:0014169 | decreased brown adipose tissue mass | decreased physical bulk or volume of brown adipose tissue |
HP:0001945 | Fever | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
HP:0007663 | Reduced visual acuity | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
HP:0000508 | Ptosis | MP:0020321 | increased vascular endothelial cell apoptosis | increase in the timing or the number of vascular endothelial cells undergoing programmed cell death |
HP:0002315 | Headache | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
HP:0000802 | Impotence | MP:0012504 | increased forebrain apoptosis | increase in the number of cells of the forebrain undergoing programmed cell death |
HP:0002893 | Pituitary adenoma | MP:0014167 | ectopic bone | the appearance of an extra bone structure at an atypical location |
HP:0001259 | Coma | MP:0020216 | decreased circulating complement protein level | less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes |
HP:0000824 | Growth hormone deficiency | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
HP:0000622 | Blurred vision | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
HP:0008202 | Prolactin deficiency | MP:0014198 | absent pituitary infundibular stalk | absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland |
HP:0100829 | Galactorrhea | MP:0014167 | ectopic bone | the appearance of an extra bone structure at an atypical location |
HP:0011499 | Mydriasis | MP:0009862 | abnormal aorta elastic tissue morphology | any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the aorta wall |
HP:0002017 | Nausea and vomiting | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
HP:0000876 | Oligomenorrhea | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
HP:0011748 | Adrenocorticotropic hormone deficiency | MP:0011957 | decreased compensatory feeding amount | decreased amount of food consumed after a period of fasting |
HP:0000863 | Central diabetes insipidus | MP:0013282 | urinary bladder exstrophy | a herniation of the urinary bladder through an anterior abdominal wall defect; refers to congenital absence of a portion of the lower anterior abdominal wall and the anterior urinary bladder wall, with eversion of the posterior bladder wall through the de |
HP:0012378 | Fatigue | MP:0013659 | abnormal erythroid lineage cell morphology | any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes |
HP:0000651 | Diplopia | MP:0020187 | altered susceptibility to prion infection | altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is |
HP:0001895 | Normochromic anemia | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
HP:0001943 | Hypoglycemia | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
HP:0000870 | Prolactin excess | MP:0014167 | ectopic bone | the appearance of an extra bone structure at an atypical location |
HP:0001262 | Somnolence | MP:0013504 | increased embryonic tissue cell apoptosis | increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death |
HP:0040075 | Hypopituitarism | MP:0011495 | abnormal head shape | any anomaly in the characteristic surface outline or contour of a head of an organism |
HP:0000980 | Pallor | MP:0020186 | altered susceptibility to bacterial infection | a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria |
HP:0000613 | Photophobia | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
HP:0001289 | Confusion | MP:0020187 | altered susceptibility to prion infection | altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is |
HP:0002615 | Hypotension | MP:0020214 | susceptible to malignant hyperthermia | increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine |
HP:0002902 | Hyponatremia | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
HP:0008245 | Pituitary hypothyroidism | MP:0020087 | increased susceptibility to non-insulin-dependent diabetes | increased likelihood to develop non-insulin-dependent diabetes |
HP:0000815 | Hypergonadotropic hypogonadism | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
HP:0000822 | Hypertension | MP:0020216 | decreased circulating complement protein level | less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes |
HP:0006824 | Cranial nerve paralysis | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
Disease ID | 759 |
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Disease | pituitary apoplexy |
Case | (Waiting for update.) |